Chronic Electrical Stimulation for Tear Secretion: Lacrimal vs. anterior ethmoid nerve

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Enhanced Tearing by Electrical Stimulation of the Anterior Ethmoid Nerve

Purpose Electrical neurostimulation enhances tear secretion, and can be applied to treatment of dry eye disease. Using a chronic implant, we evaluate the effects of stimulating the anterior ethmoid nerve on the aqueous, lipid, and protein content of secreted tears. Methods Neurostimulators were implanted beneath the nasal mucosa in 13 New Zealand white rabbits. Stimulations (2.3-2.8 mA pulses...

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OBJECTIVE To study electrical stimulation of the lacrimal gland and afferent nerves for enhanced tear secretion, as a potential treatment for dry eye disease. We investigate the response pathways and electrical parameters to safely maximize tear secretion. APPROACH We evaluated the tear response to electrical stimulation of the lacrimal gland and afferent nerves in isofluorane-anesthetized ra...

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ژورنال

عنوان ژورنال: The Ocular Surface

سال: 2019

ISSN: 1542-0124

DOI: 10.1016/j.jtos.2019.08.012